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Bell, Graeme

One or more keywords matched the following properties of Bell, Graeme

Property	Value
keywords	Genetics of diabetes
overview	Dr. Bell's research program focuses on the genetics of diabetes and other metabolic disorders.

One or more keywords matched the following items that are connected to Bell, Graeme

Item Type	Name
Concept	Genetics, Population
Concept	Mice, Transgenic
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C57BL
Concept	Mice, Obese
Concept	Mice, Knockout
Concept	Mice
Concept	Antisense Elements (Genetics)
Concept	Mice, Mutant Strains
Concept	Mice, SCID
Concept	Mice, Inbred NOD
Academic Article	Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Academic Article	Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
Academic Article	Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1.
Academic Article	Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism.
Academic Article	Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
Academic Article	Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Academic Article	Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.
Academic Article	MODY: a model for the study of the molecular genetics of NIDDM.
Academic Article	Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
Academic Article	Differential expression of somatostatin receptor subtypes in brain.
Academic Article	Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
Academic Article	Calpains play a role in insulin secretion and action.
Academic Article	A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
Academic Article	Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.
Academic Article	Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
Academic Article	RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
Academic Article	Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1.
Academic Article	Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.
Academic Article	Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
Academic Article	Anti-diabetic effect of ginsenoside Re in ob/ob mice.
Academic Article	Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
Academic Article	Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in MIP-luc transgenic mice.
Academic Article	Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
Academic Article	Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.
Academic Article	Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.
Academic Article	Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice.
Academic Article	Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and ß-cell regeneration.
Academic Article	MODY: history, genetics, pathophysiology, and clinical decision making.
Academic Article	An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.
Academic Article	Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.
Academic Article	Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.
Academic Article	Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2.
Academic Article	Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.
Academic Article	Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.
Academic Article	Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Academic Article	Immunological detection of isoforms of the somatostatin receptor subtype, SSTR2.
Academic Article	Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
Academic Article	Structure and function of ASP, the human homolog of the mouse agouti gene.
Academic Article	Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
Academic Article	A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.
Academic Article	In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
Academic Article	Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
Academic Article	Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.
Academic Article	Organ alchemy: producing insulin in the liver.
Academic Article	5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Academic Article	Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic ß-cells.
Academic Article	Cloning of rat and mouse P2Y purinoceptors.
Academic Article	Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
Academic Article	Distribution of kappa opioid receptor mRNA in adult mouse brain: an in situ hybridization histochemistry study.
Academic Article	Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.
Academic Article	A tyrosine phosphatase is associated with the somatostatin receptor.
Academic Article	Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20.
Academic Article	Intrapancreatic delivery of human umbilical cord blood aldehyde dehydrogenase-producing cells promotes islet regeneration.
Academic Article	Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.
Academic Article	In vitro scan for enhancers at the TCF7L2 locus.
Academic Article	Purification of multiple heat shock proteins from a single tumor sample.
Academic Article	Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
Academic Article	Genetics and pathophysiology of neonatal diabetes mellitus.
Academic Article	GSK-3ß function in bone regulates skeletal development, whole-body metabolism, and male life span.
Academic Article	Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.
Academic Article	Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.
Academic Article	Sex and the spread of retrotransposon Ty3 in experimental populations of Saccharomyces cerevisiae.
Academic Article	Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
Academic Article	Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia.
Academic Article	Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Grant	Diabetes Research and Training Center
Grant	Diabetes Research and Training Center
Grant	Functional follow-up of the association between TCF7L2 and T2D
Grant	Transcriptional Regulatory Networks in Pancreatic Islets

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genetics